The common pain-killer which was popular in the 17th-18th centuries:

 

2 ounces of opium;

1 ounce of saffron;

a drachm of cinnamon and cloves

- all dissolved in a pint of Canary wine.

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To your happy health!

This is how Opium poppy (Papaver somniferum) grows in the wild. Watch out!
Artist: Unknown

Do you know some more natural pain-killers?